Wakix is available in tablet form.
What Is Wakix Used For?
The Food and Drug Administration (FDA) approved Wakix to treat certain symptoms of narcolepsy, including excessive daytime sleepiness and cataplexy.
Brand Name: Wakix
Drug Availability: Prescription
Administration Route: Oral
Therapeutic Classification: Central nervous system agent
Available Generically: No
Controlled Substance: N/A
Active Ingredient: Pitolisant
Dosage Form: Tablet
Cataplexy describes an episode of temporary muscle weakness triggered by a strong emotional response, such as laughter or anger. During an attack, people with cataplexy may notice their head falls forward, their jaw hangs open, or their knees buckle, causing them to fall. Muscle tone usually resolves within 2 minutes.
How to Take Wakix
Wakix comes as an oral tablet that you take once daily in the morning, as soon as you wake up. Follow your healthcare provider’s instructions on how many tablets to take. Your healthcare provider may slowly increase your dose of Wakix over several weeks to achieve the best response.
Storage
Store Wakix at room temperature (between 68 and 77 degrees Fahrenheit). Keep Wakix—and all your medicines—in a safe location, up high and out of the reach of children.
What Are the Side Effects of Wakix?
This is not a complete list of side effects and others may occur. A healthcare provider can advise you on side effects. If you experience other effects, contact your pharmacist or a healthcare provider. You may report side effects to the FDA at fda.gov/medwatch or 1-800-FDA-1088.
Common Side Effects
Some people may experience side effects while taking Wakix. Let your healthcare provider know about any side effects that bother you or don’t go away. Common side effects include:
Anxiety Headache Muscle pain Nausea Signs of the common cold Trouble sleeping
Severe Side Effects
Rarely, Wakix may cause serious side effects. Call your healthcare provider right away if you have any severe reactions. Call 911 if your symptoms feel life-threatening or think you are having a medical emergency.
Heart Rhythm Problems (Arrhythmias)
Wakix can affect the electrical activity in your heart and rarely lead to serious heart rhythm problems. Let your healthcare provider know if you:
Develop heart palpitations Feel lightheaded Lose consciousness (pass out)
Allergic Reactions
Signs of an allergic reaction include:
Swelling of the mouth, face, lips, tongue, or throatDifficulty breathingRashHivesTightness in the chest or throat.
Dosage: How Much Wakix Should I Take?
Missed Dose
If you forget to take your dose of Wakix, skip your dose for that day. Take your next dose the following morning when you wake up. Do not double up or take extra doses.
If you experience a serious side effect, you or your provider may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting Program or by phone (800-332-1088).
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For oral dosage form (tablets): For cataplexy or excessive daytime sleepiness caused by narcolepsy: Adults—At first, 8. 9 milligrams (mg) (two tablets of 4. 45 mg) once a day on Week 1. Your doctor may increase your dose to 17. 8 mg (one tablet of 17. 8 mg) once a day on Week 2. Then, your doctor may increase your dose to 35. 6 mg (two tablets of 17. 8 mg) once a day on Week 3. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 35. 6 mg per day. Children—Use and dose must be determined by your doctor.
Overdose: What Happens If I Take Too Much Wakix?
An overdose of Wakix may cause:
HeadacheTrouble sleepingIrritabilityNauseaStomach pain
It is important only to take your prescribed dose of Wakix. Ask your healthcare provider or pharmacist if you are unsure how much to take.
Precautions
What Are Reasons I Shouldn’t Take Wakix?
Certain conditions increase your risk of developing complications from Wakix. Don’t take Wakix if you:
If someone collapses or isn’t breathing after taking Wakix, call 911 immediately.
This medicine does not take the place of getting enough sleep. It should not be used for occasional sleepiness that has not been diagnosed as narcolepsy. Ask your doctor for advice about good sleep habits.
Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.
Birth control pills may not work while you are using pitolisant. To keep from getting pregnant, use another form of birth control during treatment and for at least 21 days after your last dose. Other forms of birth control include condoms, diaphragms, or contraceptive foams or jellies.
It is important to tell your doctor if you become pregnant. Your doctor may want you to join a pregnancy exposure registry for patients taking this medicine.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Are allergic to pitolisant or any other ingredient in WakixHave severe liver problems
What Other Medications Interact With Wakix?
Many drugs can interact with Wakix. Be sure to let your healthcare provider know about all the medicines you take—even over-the-counter, nonprescription products.
Wakix can decrease the effectiveness of hormonal birth control, including birth control pills. You must use a non-hormonal form of birth control (e.g., condoms, an IUD, a diaphragm with contraceptive jelly) while taking Wakix and for 21 days after stopping Wakix.
Some drugs can increase Wakix levels. Your healthcare provider may reduce your dose of Wakix if you take:
Paxil (paroxetine) Prozac (fluoxetine) Quinidine Wellbutrin (bupropion)
Certain medicines increase your risk of developing heart rhythm problems from Wakix. Let your healthcare provider know if you take:
Betapace (sotalol) Chlorpromazine Geodon (ziprasidone) Methadone Multaq (dronedarone) Norpace (disopyramide) Pacerone (amiodarone) Quinidine Thioridazine Tikosyn (dofetilide)
Many drugs can decrease how well Wakix works, including:
Antihistamines like Benadryl (diphenhydramine) and Phenergan (promethazine) Dilantin (phenytoin) Mysoline (primidone) Phenobarbital Remeron (mirtazapine) Rifampin Tegretol (carbamazepine) Tricyclic antidepressants (TCAs) like imipramine, Anafranil (clomipramine), and Pamelor (nortriptyline)
This is not a complete list of all the drugs that may interact with Wakix. Always keep an up-to-date list of all the medicines you take, and let your healthcare provider and pharmacist know any time there are changes.
What Medications Are Similar?
Wakix belongs to a group of medications called histamine-3 inverse agonists. It is the only medication used to treat narcolepsy in this group.
Most narcolepsy medicines treat either excessive daytime sleepiness or cataplexy. Because many patients with narcolepsy experience both of these symptoms, they often need to take multiple medications. Wakix is unique because it treats both daytime sleepiness and cataplexy, so you may only need to take one drug.
How Can I Stay Healthy While Taking Wakix?
If you’re living with the symptoms of narcolepsy, just getting through the day can be a challenge. An afternoon nap can help some people improve their daytime sleepiness, but it’s not enough for most people. Fortunately, effective medications, including Wakix, are available to help relieve these symptoms.
Because Wakix may interact with many different drugs, it’s important to let your healthcare provider know about all your medicines, even over-the-counter, nonprescription products. Your provider may need to adjust your dose of Wakix to ensure you receive safe and effective treatment.
